People
Professor Angela McLean
Co-Director of the Institute of Emerging Infections
E-mail: angela.mclean@zoo.ox.ac.uk
Phone: +44 (0)1865 271210
Autobiography
I studied mathematics at Oxford followed by a PhD in biomathematics at Imperial College, London. After a brief spell in the City I joined the Mathematical Biology Group at the National Institute for Medical Research at Mill Hill. I returned to Oxford as a Royal Society University Research Fellow in 1990 and took a secondment to the Institut Pasteur in Paris in 1994. In 1998 I became Head of Mathematical Biology at the BBSRC’s Institute for Animal Health. Returning to Oxford in 2000 I became Professor of Mathematical Biology in 2004. In 2005 I became Director of the Institute for Emerging Infections – a founding Institute of the James Martin 21st Century School. Since 1st October 2008 I have been a Senior Research Fellow at All Souls College. I was elected to the Royal Society in 2009, and was awarded the Royal Society's Gabor Medal in 2011. I am currently chairing the Lead Expert Group for a Policy Futures Project on Improving Future Disaster Anticipation and Resilience for HM Government’s Foresight Programme.
Research Activities
My research interests lie in the use of mathematical models to aid our understanding of the evolution and spread of infectious agents. This encompasses modelling of the dynamics of infections and immune responses within individual hosts as well as models of the spread of infections from one host to another. My groups current research interests focus on:
- HIV
- HCV
- Influenza
- Scrapie
Selected Recent Papers
McCaw JM, Arinaminpathy N, Hurt AC, McVernon J, McLean AR. (2011) A Mathematical Framework for Estimating Pathogen Transmission Fitness and Inoculum Size Using Data from a Competitive Mixtures Animal Model. PLoS Comput Biol 7(4): e1002026
Smith JA, Aberle JH, Fleming VM, Ferenci P, Thomson EC, McLean AR, Karayiannis P, Holzmann H, Klenerman P. (2010)Dynamic coinfection with multiple viral subtypes in acute hepatitis C. Journal of Infectious Diseases Vol. 202(12), pages 1770-1779
Fryer HR, Frater J, Duda A, Roberts MG. (2010) The SPARTAC Trial Investigators, Phillips RE, McLean AR. Modelling the evolution and spread of HIV immune escape mutants. Plos Pathogens Vol. 6(11): e1001196
Fryer HR and McLean AR. (2010) Using mathematical models to explore the role of cytotoxic T lymphocytes in HIV infection’. Current mathematical models in immunology. Springer (in press).
Kubiak RJ, Arinaminpathy N, McLean AR (2010) Insights into the Evolution and Emergence of a Novel Infectious Disease.PLoS Comput Biol 6(9): e1000947Cromer D, Wolinksy SM, McLean AR (2010) How fast could HIV change gene frequencies in the human population?Proc. R. Soc. B 7 vol. 277 no. 1690
Marks A J, Pillay D, McLean A R (2010) The effect of intrinsic stochasticity on transmitted HIV drug resistence patterns. Journal of Theoretical Biology 262: 1-13
Fryer H , Scherer A, Oxenius A, Phillips R, McLean A R (2009) No evidence for competition between cytotoxic T-lymphocyte responses in HIV-1 infection. Proc. R. Soc. B. Vol. 276, No. 1677, 4389 – 4397
Huang K-H, Goedhals, D, Fryer, H, van Vuuren, C., Katzourakis, A., De Oliveira, T., Cassol, S., Seebregts, C., McLean, A. R., Klenerman, P., Phillips, R. E., Frater, J. (2009). Low CD4 cell counts are associated with pre-therapy HIV drug resistance. Antiviral Therapy. Vol 14 (7) 975-84
Arinaminpathy N., McLean A.R., (2009) Evolution and emergence of novel human infections. Proc. R. Soc. B. 273, 3075–3083
McVernon, J., Ramsay, M.E., McLean, A.R. (2008) Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. Epidemiol. Infect. 136: 800-812
Arinaminpathy N., McLean A.R. (2008) Antiviral treatment for the control of pandemic influenza: some logistical constraints. J. R. Soc Interface 5: 545-553
Fryer, H.R., Baylis, M., Sivam, K., McLean, A.R. (2007) Quantifying the risk from ovine BSE and the impact of control strategies Proc Biol Sci. 274: 1497-503
A. J. Frater, H. Brown, A. Oxenius, H. Gunthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. R. McLean, R. E. Phillips. (2007) Effective T Cell Responses Select HIV-1 Mutants and Slow Disease Progression. J. Virol 81: 6742-51
R. Asquith A.R. McLean. (2007) In vivo CD8+ T Cell Killing of Immunodeficiency Virus- Infected Cells in Humans and Macaques PNAS 104: 6365-70
R. Asquith, C.T.T. Edwards, M. Lipsitch, A. R. McLean Quantifying Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo (2006) PLOS Biology 4: e90
Downloads
Effective T Cell Responses Select HIV-1 Mutants (915k)
Quantifiable CTL Responses and HLA-related risk 2004 (750k)
Quantifying Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells 2006 (1.21 MB)